Publications

Pham, H. H., Murphy, C. T., Sureshkumar, G., Ly, D. H., Opresko, P. L. and Armitage, B. A. Cooperative hybridization of γpna miniprobes to a repeating sequence motif and application to telomere analysis Org. Biomol. Chem. 2014, 12, 7345-7354. PMID: 25115693

Manna, A., Rapireddy, S., Bahal, R., Ly, D.H. MiniPEG-gPNA. Peptide nucleic acids, Methods and Protocols, 2 ed., Humana Press, 2014, 1. PMID: 24297346

Goldman, J. M. , Zhang, L. A., Manna, A., Armitage, B. A., Ly, D. H., Schneider, J.W. High affinity gPNA sandwich hybridization assay for rapid detection of short nucleic acid targets with single mismatch discrimination. Biomacromolecules, 2013, 14, 2253.

Bahal, R., McNeer, N. A., Ly, D. H., Saltzman, W. M., Glazer, P.M. Nanoparticle for delivery of antisense gPNA oligomers targeting CCR5. Artificial DNA: PNA & XNA 2013, 4, 49. PMID: 23954968

Gupta, A., Lee, L-L., Roy, S., Tanious, F. A., Wilson, W. D., Ly, D. H., Armitage, B. A. Strand invasion of DNA quadruplexes by PNA: Comparison of homologous and complementary hybridization. ChemBioChem 2013, 14, 1476. PMID: 23868291

Delgado, E., Bahal, R., Yang, J., Jung, M. L., Ly, D. H., Satdarshan, P. S. M. β-Catenin knockdown in liver tumor cells by a cell permeable gamma guanidine-based peptide nucleic acid. Curr. Cancer Drug Targets 2013, 13, 867. PMID: 23822752

Singer, A., Rapireddy, S., Ly, D. H., Meller, A. Electronic barcoding of a viral gene at the single-molecule level. Nano Lett., 2012, 12, 1722. PMID: 22352964

Thomas, S. M., Sahu, B., Rapireddy, S., Bahal, R., Wheeler, S. E., Procopio, E. M., Kim, J., Joyce, S. C., Contrucci, S., Wang, Y., Chiosea, S. I., Lathrop, K. L., Watkins, S., Grandis, J. R., Armitage, B. A., Ly, D. H. Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models. ACS Chem. Biol. 2013, 8, 345. PMID: 23113581

Wierzbinski, E., de Leon, A., Yin, X., Balaeff, A., Davis, K. L., Rapireddy, S., Venkatramani, R., Keinan, S., Ly, D. H., Madrid, M., Beratan, D. N., Achim, C., Waldeck, D. H. Effect of backbone flexibility on charge transfer rates in peptide nucleic acid duplexes. J. Am. Chem. Soc. 2012, 134, 9335.PMID: 22548314

Rapireddy, S., Nhon, L., Meehan, R. E., Franks, J., Stolz, D. B., Tran, D., Selsted, M. E., Ly, D. H. RTD-1 mimic containing gPNA scaffold exhibits broad-spectrum antibacterial activities. J. Am. Chem. Soc. 2012, 134, 4041-4044. PMID: 22332599

Singer, A., Rapireddy, S., Ly, D. H., Meller, A. Electronic barcoding of a viral gene at the single-molecule level. Nano Lett. 2012, 12, 1722-1728. PMID: 22352964

Rapireddy, S., Bahal, R., Ly, D. H. Strand invasion of mixed-sequence, double-helical B-DNA by g-peptide nucleic acids containing G-clamp nucleobases under physiological conditions. Biochemistry, 2011, 50, 3913-3918.

Bahal, R., Sahu, B., Rapireddy, S., Lee, C-M., Ly, D. H. Sequence-unrestricted, Watson-Crick recognition of double helical B-DNA by (R)-miniPEG-gPNAs. ChemBioChem 2012, 13, 56-60. PMID: 22135012

Roy, S., Zanotti, K. J., Murphy, C. T., Tanious, F. A., Wilson, W. D., Ly, D. H., Armitage, B. A. Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes. Chem. Commun. 2011, 47, 8524-8526. PMID: 21717030

Bezer, S., Rapireddy, S., Skorik, Y. A., Ly, D. H., Achim, C. Coordination-driven inversion of handedness in ligand-modified PNA. Inorg. Chem. 2011, 50, 11929-11937. PMID: 22059624

Crawford, M. J., Rapireddy, S., Bahal, R., Sacui, I., Ly, D. H. Effect of steric constraint at the g-backbone position on the conformations and hybridization properties of PNAs. J. Nucleic Acids 2011, 652702. PMID: 21776375

Sahu, B., Sacui, I., Rapireddy, S., Zanotti, K. J., Bahal, R., Armitage, B. A., Ly, D. H. Synthesis and characterization of conformationally preorganized, (R)-diethylene glycol-containing g-peptide nucleic acids with superior hybridization properties and biocompatibility. J. Org. Chem. 2011, 76, 5614-5627.

He, W., Crawford, M. J., Rapireddy, S., Madrid, M., Gil, R. R., Ly, D. H., Achim, C. The structure of a g-modified peptide nucleic acid duplex. Mol. BioSyst. 2010, 6, 1619-1629. PMID: 20386807

Kuhn, K., Sahu, B., Rapireddy, S., Ly, D. H., Frank-Kamenetskii, M. D. Sequence specificity at targeting double-stranded DNA with a g-oligomer modified with guanidinium G-clamp nucleobases. Artificial DNA: PNA & XNA 2010, 1, 45-53. PMID: 21687526

Yeh, J., Shivachev, B., Rapireddy, S., Crawford, M. J., Gil, R. R., Du, S., Madrid, M., Ly, D. H. Crystal structure of chiral gPNA with complementary DNA strand: Insights into the stability and specificity of recognition and conformational preorganization. J. Am. Chem. Soc. 2010, 132, 10717-10727. PMID: 20681704

Lusvarghi, S., Murphy, C. T., Roy, S., Tanious, F. A., Sacui, I., Wilson, W. D., Ly, D. H., Armitage, B. A. Loop and backbone modifications of peptide nucleic acid improve G-quadruplex binding selectivity. J. Am. Chem. Soc. 2009, 131, 18415-18424. PMID: 19947597

He, G., Rapireddy, S., Bahal, R., Sahu, B., Ly, D. H. Strand invasion of extended, mixed-sequence B-DNA by gPNAs. J. Am. Chem. Soc. 2009, 131, 12088-12090. PMID: 19663424

Sahu, B., Chenna, V., Lathrop, K. L., Thomas, S. M., Zon, G., Livak, K. J., Ly, D. H. Synthesis of conformationally preorganized and cell-permeable guanidine-based g-peptide nucleic acids (gGPNAs). J. Org. Chem. 2009, 74, 1509-1516. PMID: 19161276

Chenna, V., Rapireddy, S., Sahu, B., Ausin, C., Pedroso, E., Ly, D. H. A simple cytosine to G-clamp nucleobase substitution enables chiral g-PNAs to invade mixed-sequence double-helical B-form DNA. ChemBioChem 2008, 9, 2388-2391. PMID: 18816545

Roy, S., Tanious, F. A., Wilson, W. D., Ly, D. H., Armitage, B. A. High-affinity homologous peptide nucleic acid probes for targeting a quadruplex-forming sequence from a MYC promoter element. Biochemistry 2007, 46, 10433-10443. PMID: 17718513

Rapireddy, S., He, G., Roy, S., Armitage, B. A., Ly, D. H. Strand invasion of mixed-sequence B-DNA by acridine-linked, g-peptide nucleic acid (g-PNA). J. Am. Chem. Soc. 2007, 129, 15596-15600. PMID: 18027941

Achim, C., Armitage, B. A., Ly, D. H., Schneider, J. W. Peptide nucleic acids. Wiley Encyclopedia Chemical Biology, John Wiley & Sons, Inc. 2007, 1-10.

Dragulescu-Andrasi, A., Rapireddy, S., Frezza, B. M., Gayathri, C., Gil, R. R., Ly, D. H. A simple g-backbone modification preorganizes peptide nucleic acid into a helical structure. J. Am. Chem. Soc. 2006, 128, 10258-10267. PMID: 16881656

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